Journal article
The adenosine analogue NITD008 has potent antiviral activity against human and animal caliciviruses
DE Tuipulotu, TM Fumian, NE Netzler, JM Mackenzie, PA White
Viruses | MDPI | Published : 2019
DOI: 10.3390/v11060496
Abstract
The widespread nature of calicivirus infections globally has a substantial impact on the health and well-being of humans and animals alike. Currently, the only vaccines approved against caliciviruses are for feline and rabbit-specific members of this group, and thus there is a growing effort towards the development of broad-spectrum antivirals for calicivirus infections. In this study, we evaluated the antiviral activity of the adenosine analogue NITD008 in vitro using three calicivirus model systems namely; feline calicivirus (FCV), murine norovirus (MNV), and the human norovirus replicon. We show that the nucleoside analogue (NA), NITD008, has limited toxicity and inhibits calicivirus repl..
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Awarded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Funding Acknowledgements
This work was partially funded by a National Health and Medical Research Council project grants (APP1083139 and APP1123135) awarded to JM and PW. DET and NN acknowledge support through Australian Government Research Training Program (RTP) scholarships. TMF received a Postdoctoral fellowship from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) - Brasil, Brazilian Ministry of Education (grant n: POS DOC 88881.120009/2016-01), Finance Code 001. The funding bodies had no role in the project design, data collection, analysis, interpretation, writing or decision to submit this article.